T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis.
Identifieur interne : 00CC11 ( Main/Exploration ); précédent : 00CC10; suivant : 00CC12T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis.
Auteurs : M. Yazdanbakhsh [Pays-Bas] ; W A Paxton ; Y C Kruize ; E. Sartono ; A. Kurniawan ; A. Van Het Wout ; M E Selkirk ; F. Partono ; R M MaizelsSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1993.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Activation des lymphocytes (physiologie), Adolescent, Adulte, Adulte d'âge moyen, Anticorps antihelminthe (analyse), Antigènes d'helminthe (administration et posologie), Antigènes d'helminthe (immunologie), Facteurs de l'âge, Filariose lymphatique (immunologie), Humains, Immunité cellulaire, Immunoglobuline E (analyse), Immunoglobuline G (analyse), Isotypes des immunoglobulines, Lymphocytes T (anatomopathologie), Lymphocytes T (immunologie), Lymphocytes T (physiologie), Sujet âgé, Éosinophilie (anatomopathologie).
- MESH :
- administration et posologie : Antigènes d'helminthe.
- analyse : Anticorps antihelminthe, Immunoglobuline E, Immunoglobuline G.
- anatomopathologie : Lymphocytes T, Éosinophilie.
- immunologie : Activation des lymphocytes, Antigènes d'helminthe, Filariose lymphatique, Lymphocytes T.
- physiologie : Activation des lymphocytes, Lymphocytes T.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Humains, Immunité cellulaire, Isotypes des immunoglobulines, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Antibodies, Helminth (analysis), Antigens, Helminth (administration & dosage), Antigens, Helminth (immunology), Elephantiasis, Filarial (immunology), Eosinophilia (pathology), Humans, Immunity, Cellular, Immunoglobulin E (analysis), Immunoglobulin G (analysis), Immunoglobulin Isotypes, Lymphocyte Activation (immunology), Lymphocyte Activation (physiology), Middle Aged, T-Lymphocytes (immunology), T-Lymphocytes (pathology), T-Lymphocytes (physiology).
- MESH :
- chemical , administration & dosage : Antigens, Helminth.
- chemical , analysis : Antibodies, Helminth, Immunoglobulin E, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth.
- immunology : Elephantiasis, Filarial, Lymphocyte Activation, T-Lymphocytes.
- pathology : Eosinophilia, T-Lymphocytes.
- physiology : Lymphocyte Activation, T-Lymphocytes.
- Adolescent, Adult, Age Factors, Aged, Humans, Immunity, Cellular, Immunoglobulin Isotypes, Middle Aged.
Abstract
To establish the relationships among T and B cell responses, active infection, and clinical manifestations in lymphatic filariasis, filarial-specific lymphocyte proliferation, IgG antibody isotypes, and IgE levels were determined in an exposed population: 31 asymptomatic amicrofilaremics, 43 microfilaremics, 12 symptomatic amicrofilaremics, and 52 elephantiasis patients. Lymphocyte proliferation was higher in elephantiasis patients and asymptomatic amicrofilaremics than in microfilaremics (P < .004). A proportion of asymptomatic amicrofilaremics (32%), elephantiasis patients (37%), and symptomatic amicrofilaremics (58%) showed antigen-specific lymphocyte unresponsiveness, and lymphocyte proliferation to filarial antigens correlated negatively with specific IgG4 levels (rho = -0.315, P < .001). As elevated specific IgG4 is an indicator of active infection, it is argued that active infection may result in lymphocyte hyporesponsiveness irrespective of clinical category. Of those with elevated specific IgE levels and high T cell proliferative responses, 70% had elephantiasis, suggesting these factors have a role in pathology. However, the existence of a proportion of elephantiasis patients with low anti-filarial IgE and T cell unresponsiveness to filarial antigens suggests that elephantiasis can be caused by distinct processes.
PubMed: 8450257
Affiliations:
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Yazdanbakhsh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Parasitology, Leiden University, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Parasitology, Leiden University</wicri:regionArea><wicri:noRegion>Leiden University</wicri:noRegion></affiliation></author><author><name sortKey="Paxton, W A" sort="Paxton, W A" uniqKey="Paxton W" first="W A" last="Paxton">W A Paxton</name></author><author><name sortKey="Kruize, Y C" sort="Kruize, Y C" uniqKey="Kruize Y" first="Y C" last="Kruize">Y C Kruize</name></author><author><name sortKey="Sartono, E" sort="Sartono, E" uniqKey="Sartono E" first="E" last="Sartono">E. Sartono</name></author><author><name sortKey="Kurniawan, A" sort="Kurniawan, A" uniqKey="Kurniawan A" first="A" last="Kurniawan">A. Kurniawan</name></author><author><name sortKey="Van Het Wout, A" sort="Van Het Wout, A" uniqKey="Van Het Wout A" first="A" last="Van Het Wout">A. 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Yazdanbakhsh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Parasitology, Leiden University, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Parasitology, Leiden University</wicri:regionArea><wicri:noRegion>Leiden University</wicri:noRegion></affiliation></author><author><name sortKey="Paxton, W A" sort="Paxton, W A" uniqKey="Paxton W" first="W A" last="Paxton">W A Paxton</name></author><author><name sortKey="Kruize, Y C" sort="Kruize, Y C" uniqKey="Kruize Y" first="Y C" last="Kruize">Y C Kruize</name></author><author><name sortKey="Sartono, E" sort="Sartono, E" uniqKey="Sartono E" first="E" last="Sartono">E. Sartono</name></author><author><name sortKey="Kurniawan, A" sort="Kurniawan, A" uniqKey="Kurniawan A" first="A" last="Kurniawan">A. Kurniawan</name></author><author><name sortKey="Van Het Wout, A" sort="Van Het Wout, A" uniqKey="Van Het Wout A" first="A" last="Van Het Wout">A. Van Het Wout</name></author><author><name sortKey="Selkirk, M E" sort="Selkirk, M E" uniqKey="Selkirk M" first="M E" last="Selkirk">M E Selkirk</name></author><author><name sortKey="Partono, F" sort="Partono, F" uniqKey="Partono F" first="F" last="Partono">F. Partono</name></author><author><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Antibodies, Helminth (analysis)</term><term>Antigens, Helminth (administration & dosage)</term><term>Antigens, Helminth (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Eosinophilia (pathology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoglobulin E (analysis)</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin Isotypes</term><term>Lymphocyte Activation (immunology)</term><term>Lymphocyte Activation (physiology)</term><term>Middle Aged</term><term>T-Lymphocytes (immunology)</term><term>T-Lymphocytes (pathology)</term><term>T-Lymphocytes (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term><term>Activation des lymphocytes (physiologie)</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antihelminthe (analyse)</term><term>Antigènes d'helminthe (administration et posologie)</term><term>Antigènes d'helminthe (immunologie)</term><term>Facteurs de l'âge</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunoglobuline E (analyse)</term><term>Immunoglobuline G (analyse)</term><term>Isotypes des immunoglobulines</term><term>Lymphocytes T (anatomopathologie)</term><term>Lymphocytes T (immunologie)</term><term>Lymphocytes T (physiologie)</term><term>Sujet âgé</term><term>Éosinophilie (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin E</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline E</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes T</term><term>Éosinophilie</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Antigènes d'helminthe</term><term>Filariose lymphatique</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphocyte Activation</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Eosinophilia</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphocyte Activation</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoglobulin Isotypes</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de l'âge</term><term>Humains</term><term>Immunité cellulaire</term><term>Isotypes des immunoglobulines</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To establish the relationships among T and B cell responses, active infection, and clinical manifestations in lymphatic filariasis, filarial-specific lymphocyte proliferation, IgG antibody isotypes, and IgE levels were determined in an exposed population: 31 asymptomatic amicrofilaremics, 43 microfilaremics, 12 symptomatic amicrofilaremics, and 52 elephantiasis patients. Lymphocyte proliferation was higher in elephantiasis patients and asymptomatic amicrofilaremics than in microfilaremics (P < .004). A proportion of asymptomatic amicrofilaremics (32%), elephantiasis patients (37%), and symptomatic amicrofilaremics (58%) showed antigen-specific lymphocyte unresponsiveness, and lymphocyte proliferation to filarial antigens correlated negatively with specific IgG4 levels (rho = -0.315, P < .001). As elevated specific IgG4 is an indicator of active infection, it is argued that active infection may result in lymphocyte hyporesponsiveness irrespective of clinical category. Of those with elevated specific IgE levels and high T cell proliferative responses, 70% had elephantiasis, suggesting these factors have a role in pathology. However, the existence of a proportion of elephantiasis patients with low anti-filarial IgE and T cell unresponsiveness to filarial antigens suggests that elephantiasis can be caused by distinct processes.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Kruize, Y C" sort="Kruize, Y C" uniqKey="Kruize Y" first="Y C" last="Kruize">Y C Kruize</name><name sortKey="Kurniawan, A" sort="Kurniawan, A" uniqKey="Kurniawan A" first="A" last="Kurniawan">A. Kurniawan</name><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name><name sortKey="Partono, F" sort="Partono, F" uniqKey="Partono F" first="F" last="Partono">F. Partono</name><name sortKey="Paxton, W A" sort="Paxton, W A" uniqKey="Paxton W" first="W A" last="Paxton">W A Paxton</name><name sortKey="Sartono, E" sort="Sartono, E" uniqKey="Sartono E" first="E" last="Sartono">E. Sartono</name><name sortKey="Selkirk, M E" sort="Selkirk, M E" uniqKey="Selkirk M" first="M E" last="Selkirk">M E Selkirk</name><name sortKey="Van Het Wout, A" sort="Van Het Wout, A" uniqKey="Van Het Wout A" first="A" last="Van Het Wout">A. Van Het Wout</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M" last="Yazdanbakhsh">M. Yazdanbakhsh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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